政策法规现行有效美国危险品合规

§ 173.133 Assignment of packing group and hazard zones for Division 6.1 materials.

效力	法规类型	发布日期	生效日期	发文机构
现行有效	部门规章	2026-08-07	2026-09-08	Code of Federal Regulations (CFR) - Transportation (Title 49)

发布08-07

生效09-08

摘要总结AI 辅助解读

该法规（49 CFR § 173.133）规定了美国运输部对第6.1类毒性物质（Division 6.1）的包装组别（Packing Group）和危险区域（Hazard Zone）的判定标准。核心内容包括：依据口服、皮肤接触及吸入毒性数据确定PG I/II/III；针对吸入蒸气毒性液体，结合饱和蒸气浓度与LC50值划分Hazard Zone A/B/C；混合物可通过计算或动物实验判定分类。若不同途径毒性等级不一致，取最高毒性等级。此规定直接影响危险品申报、标签粘贴及运输资质要求。

(a) The packing group of Division 6.1 materials shall be as assigned in column 5 of the § 172.101 table. When the § 172.101 table provides more than one packing group or hazard zone for a hazardous material, the packing group and hazard zone shall be determined by applying the following criteria:

- (1) The packing group assignment for routes of administration other than inhalation of vapors shall be in accordance with the following table:

Packing group Oral toxicity LD 50 (mg/kg) Dermal toxicity LD 50 (mg/kg) Inhalation toxicity by dusts and mists LC 50 (mg/L) I ≤5.0 ≤50 ≤0.2 II >5.0 and ≤50 >50 and ≤200 >0.2 and ≤2.0 III >50 and ≤300 >200 and ≤1000 >2.0 and ≤4.0

(2)(i) The packing group and hazard zone assignments for liquids (see § 173.115(c) of this subpart for gases) based on inhalation of vapors shall be in accordance with the following table:

Packing Group Vapor concentration and toxicity I (Hazard Zone A) V ≥500 LC 50 and LC 50 ≤200 mL/M 3 . I (Hazard Zone B) V ≥10 LC 50 ; LC 50 ≤1000 mL/m 3 ; and the criteria for Packing Group I, Hazard Zone A are not met. II V ≥LC 50 ; LC 50 ≤3000 mL/m 3 ; and the criteria for Packing Group I, are not met. III V ≥.2 LC 50 ; LC 50 ≤5000 mL/m 3 ; and the criteria for Packing Groups I and II, are not met. Note 1: V is the saturated vapor concentration in air of the material in mL/m 3 at 20 °C and standard atmospheric pressure. Note 2: A liquid in Division 6.1 meeting criteria for Packing Group I, Hazard Zones A or B stated in paragraph (a)(2) of this section is a material poisonous by inhalation subject to the additional hazard communication requirements in §§ 172.203(m), 172.313 and table 1 of § 172.504(e) of this subchapter.

- (ii) These criteria are represented graphically in Figure 1:

EC02MR91.063

- (3) When the packing group determined by applying these criteria is different for two or more (oral, dermal or inhalation) routes of administration, the packing group assigned to the material shall be that indicated for the highest degree of toxicity for any of the routes of administration.

- (4) Notwithstanding the provisions of this paragraph, the packing group and hazard zone of a tear gas substance is as assigned in column 5 of the § 172.101 table.

(b) The packing group and hazard zone for Division 6.1 mixtures that are poisonous (toxic) by inhalation may be determined by one of the following methods:

- (1) Where LC 50 data is available on each of the poisonous (toxic) substances comprising the mixture—

(i) The LC 50 of the mixture is estimated using the formula:

ER07SE04.000

where f i = mole fraction of the i th component substance of the liquid. LC 50 i = mean lethal concentration of the i th component substance in mL/m 3

- (ii) The volatility of each component substance is estimated using the formula:

ER28SE01.023

where: P i = partial pressure of the i th component substance in kPa at 20 °C and one atmospheric pressure. Pi may be calculated according to Raoult's Law using appropriate activity coefficients. Where activity coefficients are not available, the coefficient may be assumed to be 1.0.

- (iii) The ratio of the volatility to the LC 50 is calculated using the formula:

ER07SE04.001

- (iv) Using the calculated values LC 50 (mixture) and R, the packing group for the mixture is determined as follows:

Packaging group (hazard zone) Ratio of volatility and LC 50 I (Hazard Zone A) R ≥500 and LC 50 (mixture) ≤200 mL/m 3 . I (Hazard Zone B) R ≥10 and LC 50 (mixture) ≤1000 mL/m 3 ; and the criteria for Packing Group I, Hazard Zone A are not met. II R ≥1 and LC 50 (mixture) ≤3000 mL/m 3 ; and the criteria for Packing Group I, Hazard Zones A and B are not met. III R ≥ 1/5 and LC 50 (mixture) ≤5000 mL/m 3 ; and the criteria for Packing Group I, Hazard Zones A and B and Packing Group II are not met.

- (2) In the absence of LC 50 data on the poisonous (toxic) constituent substances, the mixture may be assigned a packing group and hazard zone based on the following simplified threshold toxicity tests. When these threshold tests are used, the most restrictive packing group and hazard zone must be determined and used for the transportation of the mixture.

(i) A mixture is assigned to Packing Group I, Hazard Zone A only if both the following criteria are met:
(A) A sample of the liquid mixture is vaporized and diluted with air to create a test atmosphere of 200 mL/m 3 vaporized mixture in air. Ten albino rats (five male and five female) are exposed to the test atmosphere as determined by an analytical method appropriate for the material being classified for one hour and observed for fourteen days. If five or more of the animals die within the fourteen-day observation period, the mixture is presumed to have an LC 50 equal to or less than 200 mL/m 3 .
(B) A sample of the vapor in equilibrium with the liquid mixture is diluted with 499 equal volumes of air to form a test atmosphere. Ten albino rats (five male and five female) are exposed to the test atmosphere for one hour and observed for fourteen days. If five or more of the animals die within the fourteen-day observation period, the mixture is presumed to have a volatility equal to or greater than 500 times the mixture LC 50 .

- (ii) A mixture is assigned to Packing Group I, Hazard Zone B only if both the following criteria are met, and the mixture does not meet the criteria for Packing Group I, Hazard Zone A:

(A) A sample of the liquid mixture is vaporized and diluted with air to create a test atmosphere of 1000 mL/m 3 vaporized mixture in air. Ten albino rats (five male and five female) are exposed to the test atmosphere for one hour and observed for fourteen days. If five or more of the animals die within the fourteen-day observation period, the mixture is presumed to have an LC 50 equal to or less than 1000 mL/m 3 .
(B) A sample of the vapor in equilibrium with the liquid mixture is diluted with 9 equal volumes of air to form a test atmosphere. Ten albino rats (five male and five female) are exposed to the test atmosphere for one hour and observed for fourteen days. If five or more of the animals die within the fourteen-day observation period, the mixture is presumed to have a volatility equal to or greater than 10 times the mixture LC 50 .

- (iii) A mixture is assigned to Packing Group II only if both the following criteria are met, and the mixture does not meet the criteria for Packing Group I (Hazard Zones A or B):

(A) A sample of the liquid mixture is vaporized and diluted with air to create a test atmosphere of 3000 mL/m 3 vaporized mixture in air. Ten albino rats (five male and five female) are exposed to the test atmosphere for one hour and observed for fourteen days. If five or more of the animals die within the fourteen-day observation period, the mixture is presumed to have an LC 50 equal to or less than 3000 mL/m 3 .
(B) A sample of the vapor in equilibrium with the liquid mixture is used to form a test atmosphere. Ten albino rats (five male and five female) are exposed to the test atmosphere for one hour and observed for fourteen days. If five or more of the animals die within the fourteen-day observation period, the mixture is presumed to have a volatility equal to or greater than the mixture LC 50 .

- (iv) A mixture is assigned to Packing Group III only if both the following criteria are met, and the mixture does not meet the criteria for Packing Groups I (Hazard Zones A or B) or Packing Group II (Hazard Zone C):

(A) A sample of the liquid mixture is vaporized and diluted with air to create a test atmosphere of 5000 mL/m 3 vaporized mixture in air. Ten albino rats (five male and five female) are exposed to the test atmosphere for one hour and observed for fourteen days. If five or more of the animals die within the fourteen-day observation period, the mixture is presumed to have an LC 50 equal to or less than 5000 mL/m 3 .
(B) The vapor pressure of the liquid mixture is measured and if the vapor concentration is equal to or greater than 1000 mL/m 3 , the mixture is presumed to have a volatility equal to or greater than 1/5 the mixture LC 50 .
(c) Transitional provisions. The criteria for packing group assignments in effect on December 31, 2006, may continue to be used until January 1, 2012.

[Amdt. 173-224, 55 FR 52634, Dec. 21, 1990, as amended at 56 FR 66268, Dec. 20, 1991; 57 FR 45461, Oct. 1, 1992; Amdt. 173-234, 58 FR 51532, Oct. 1, 1993; Amdt. 173-138, 59 FR 49133, Sept. 26, 1994; Amdt. 173-255, 61 FR 50626, Sept. 26, 1996; 66 FR 45183, 45380, Aug. 28, 2001; 66 FR 49556, Sept. 28, 2001; 69 FR 54046, Sept. 7, 2004; 71 FR 54395, Sept. 14, 2006; 71 FR 78631, Dec. 29, 2006; 74 FR 53188, Oct. 16, 2009; 76 FR 43529, July 20, 2011]